Confusion About Testosterone Therapy and Prostate Cancer

testosterone therapy

One of the most commonly cited side effects for hormone replacement therapy as a cure to low testosterone in men is an increased risk of prostate cancer. However, much like with the Million Woman Study that linked HRT for men and breast cancer, the evidence corroborating this belief is dated and likely false. In fact, according to some modern research, low testosterone is actually a risk factor FOR types of male cancer.


The origins of the theory that testosterone replacement increased the risk of prostate cancer go back to research done at the University of Chicago in the 1940s by a group led by urologist Charles Huggins. Based on experiments performed first on dogs and then on humans, Huggins’ group concluded that prostate cancer was androgen dependent – when testosterone levels were high, the cancer worsened, but when the levels were lowered, the cancer shrank. Huggins’ theory led to surgical castration – removal of the testicles – becoming the standard treatment for prostate cancer because of the resultant drop in testosterone. Huggins was awarded a Nobel Prize in 1966 for these contributions to medical research.

hrt for men


Huggins’ findings led scientists and doctors to believe for many years that testosterone levels and prostate cancer occurrence were linked, despite the fact that his experiments didn’t test nor prove this and were limited to small numbers of test subjects. This caused medical professionals to be skeptical of hormone replacement therapy, fearing that it could lead to the development of prostate cancer. Many shied away from prescribing HRT, despite its benefits.


As time went on, more research was done, and studies showed that men with low testosterone seemed to develop prostate cancer at a higher than average rate, and that testosterone only caused progression of cancer of the prostate in men who had been castrated, and not in men who still produced testosterone naturally. The supposed link between testosterone and prostate cancer had to be reexamined.


Eventually, the medical community began to change its tune as it was presented with new evidence. A number of studies done in the 2000s, including ones published by the New England Journal of Medicine and the Mayo Clinic, showed no correlation between elevated testosterone levels and cancer of the prostate. Separate studies done by Abraham Morgentaler, a leading doctor in the field, showed that raising the levels of testosterone in men already diagnosed with prostate cancer caused no further progression of the disease, and that men in the lower range of testosterone levels are actually more at risk of developing prostate cancer than men with higher amounts. It’s now become clear that the relationship between testosterone and cancer of the prostate was misunderstood for much of the 20th century, and that hormone replacement as a means of supplementing low testosterone levels in men won’t cause the disease.


So if you’re a man who suspects he may have low testosterone, and are considering hormone replacement therapy, you can rest easy. HRT won’t give you prostate cancer; in fact, it might help prevent it.

The Male Menopause Test

The Male Menopause Test Is A Test You Don’t Want To Pass
The problem of Andropause, and the symptoms of Male Menopause, are comparable to the ones women experience, and can every now and then, be as negative. However, male menopause does not at all affect all men, at least not with the same inclusivity. Only some of the men amid the age of forty and fifty will face the condition, and it’s symptoms of Andropause. Over fifty, there is a sharp spike in the amount of men that will fall victim to this bothersome syndrome.
All the changes brought on by Andropause, that happen in each man throughout the male menopausal period, could affect every aspect of their lives. Male menopause is recognized as a physical condition, but manifests in personal, psychological, social and spiritual dimensions.
Men, like women, also encounter hormonal fluctuations that affect their sexuality, mood, and personality. Both men and women experience sexual difficulties as a result of the hormonal imbalance, but only men suffer from Erectile Dysfunction, which could be mentally devastating.
All men going through Andropause, can go through hormonal changes, that will significantly affect their lives. The levels of sexual hormones will diminish at their mid-life, and may have symptoms which are usually complementary with male menopause. It is necessary to note that each man has a distinctive chemistry, and their individual levels of hormonal loss may vary widely.
As the level of hormones decrease, it can bring on the decrease in sex drive, and the general well being of their health. The occurrence of these problems will also lead to the increase of depression, and weight gain, and definitely will change the day to day living, as compared to their lives before the onset of Andropause, or Male Menopause.
Throughout the Andropausal period, some men can face Erectile Dysfunction problems, with regards to impotence. It is the constant inability to achieve and maintain an erection, that is enough to have a satisfactory sexual performance. And for the reason of impotency, men will have abated sexual desires.
How could a man recognize that he is going through that specific stage in life, the Andropausal period? There are some symptoms to be aware of. Some are physical, some are psychological, and some are sexual. The following are the symptoms that a male is going through a male menopausal period.
Physical symptoms of male menopause include:

  1. Recovery from injuries and disease takes longer
  2. Less capacity for physical activity
  3. Increase of weight
  4. Difficulty reading small print
  5. Depletion or thinning of hair
  6. Sleep restlessness
  7. Low libido
  8. Deficiency of energy
    Cerebral symptoms of male menopause include:
  9. Exasperation
  10. Hesitancy or difficulty in making decisions
  11. Worry and fear for life
  12. Bleakness
  13. Low self-esteem, self-confidence and joy
  14. Loss of purpose, and direction in life
  15. Feeling alone, unattractive, and unloved
  16. Lack of memory and dilemma in concentrating
  17. Mood swings
    Sexual symptoms of male menopause include:
  18. Decreased sex drive
  19. Anxiety of sexual impotency
  20. More bonding problems, and fights happen with regards to sex, love, and intimacy
  21. Erectile Dysfunction, incapacity to get erect all through intimacy
  22. Increase of allure to a much younger, opposite sex
    All the symptoms that a male can go through during the male menopausal period could be treated. Although men have been suffering from either physical, emotional or sexual symptoms of male menopause, you need to control it, not through attempting self-diagnosis, but by speaking to a doctor. This will lead to being better informed, and getting the proper treatment to diminish the symptoms of the syndrome. There are several treatments for lowered male hormones, that constitute either natural, or pharmaceutical drugs. Going Natural is always better, to avoid unwanted, and sometimes severe, side effects.
    There is a specific mixture of vitamins, herbs and amino acids, that will alleviate the symptoms of Andropause and Erectile Dysfunction. You can read more about this at my web site.
    Please visit:
    Good Luck,
    Steve Stanley

Affects Of Low Testosterone And And Its Therapy Over Transgender Men

Testosterone – male sex hormone affects greatly the overall health, whether found in abundance or in reduced quantities. Various diseases from heart to lungs are caused due to disturbances in the level of hormones, naturally happening with age.
Heart and testosterone levels – How It Affects Heart?
Low testosterone level or above normal is a major reason of many heart issues.
Androgen therapy lowers the good cholesterol and increases the level of low-density lipid that is also termed as bad lipid. This also improves the quantity of triglycerides in body.

More fat is accumulated in the abdominal area as compared to lower portions that poses a serious cardiovascular risk.

Weight gain is common with testosterone therapy that lowers the sensitivity toward insulin. It allows more chances of getting Type II diabetes.

High testosterone levels in some men result in lowering the associated risk of heart disease.

Abusing levels of androgen have some clear connection with strokes and cardiac arrest.

Androgen therapy when used along with smoking and high blood pressure can become a serious threat for a body.
Hair – The Victim Of Low Testosterone
Androgen especially DHT is highly influential over hair follicles.

Androgen therapy may lead toward male baldness in some cases.

Testosterone when converts into DHT is found in two enzyme types. Type 2 is responsible for male baldness.
Gynecological Symptoms Of Low Testosterone
Testosterone therapy is used in trans-men to stop menstruation. This therapy works within five months of start and if it does not happen then expert consultation becomes necessary.

Clitoris size is increased because of testosterone therapy, a condition known as clitoromegaly. It is advised to stop the use of testosterone if this situation happens.

Polycystic ovary syndrome may occur after a long-term treatment of androgen therapy. If this condition is left untreated, there are chances of developing endometrial cancer and reduced fertility. Transgender men need to be careful about that.
Determining Endometrial Cancer
The apparent symptoms of endometrial cancer are bleeding in women passing through postmenopausal stage. In transgender men, if bleeding persists after stoppage of menstruation the endometrial biopsy should be the first thing to go for. Following procedures can also help in ruling out the chances of endometrial cancer and affects of testosterone therapy:
Ultrasounds of endometrial should be taken after every two years. If endometrial appears thin in ultrasound, a biopsy should be the next step.

Expert doctors advise adults who have a cervix or uterus to go through a Pap smear test. This test is helpful in determining the chances of cervical cancer. Cervical cancer actually occurs because of a virus transmitted sexually. There are less chances of developing cervical cancer in men who never experienced vaginal sex.

Androgen therapy also results in reduced size of breast in some transgender men. In real, this happens due to fat loss in breast area.

Another common thing that happens with women going through androgen therapy is vaginal dryness and vaginal atrophy. This condition can be improved with estrogen cream as prescribed by your doctor.

Enhanced sex drive is also observed in Trans men who undergo androgen therapy, but this slows down after few years of testosterone therapy.
Balancing low testosterone through natural means may lower the associated side effects.

Source – https://www.totaltclinic.com